Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.

Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.

Source :

• Cancer research [ 1538-7445 ] ; 2009.

Descripteurs français

• KwdFr :
  • Animaux, Autophagie (), Cellules HCT116, Chloroquine (pharmacologie), Femelle, Glycogen Synthase Kinase 3 (métabolisme), Humains, Lignée cellulaire tumorale, Phosphoryl-choline (analogues et dérivés), Phosphoryl-choline (pharmacologie), Phosphorylation (), Protein kinases (métabolisme), Protéine oncogène v-akt (métabolisme), Protéines F-box (métabolisme), Protéines du cycle cellulaire (métabolisme), Souris, Souris nude, Sérine-thréonine kinases TOR, Tests d'activité antitumorale sur modèle de xénogreffe, Transduction du signal (), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (métabolisme), Tumeurs du poumon (traitement médicamenteux), Ubiquitin-protein ligases (métabolisme).
• MESH :
  • analogues et dérivés : Phosphoryl-choline.
  • anatomopathologie : Tumeurs du poumon.
  • métabolisme : Glycogen Synthase Kinase 3, Protein kinases, Protéine oncogène v-akt, Protéines F-box, Protéines du cycle cellulaire, Tumeurs du poumon, Ubiquitin-protein ligases.
  • pharmacologie : Chloroquine, Phosphoryl-choline.
  • traitement médicamenteux : Tumeurs du poumon.
  • Animaux, Autophagie, Cellules HCT116, Femelle, Humains, Lignée cellulaire tumorale, Phosphorylation, Souris, Souris nude, Sérine-thréonine kinases TOR, Tests d'activité antitumorale sur modèle de xénogreffe, Transduction du signal.

English descriptors

• KwdEn :
  • Animals, Autophagy (drug effects), Cell Cycle Proteins (metabolism), Cell Line, Tumor, Chloroquine (pharmacology), F-Box Proteins (metabolism), F-Box-WD Repeat-Containing Protein 7, Female, Glycogen Synthase Kinase 3 (metabolism), HCT116 Cells, Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (metabolism), Lung Neoplasms (pathology), Mice, Mice, Nude, Oncogene Protein v-akt (metabolism), Phosphorylation (drug effects), Phosphorylcholine (analogs & derivatives), Phosphorylcholine (pharmacology), Protein Kinases (metabolism), Signal Transduction (drug effects), TOR Serine-Threonine Kinases, Ubiquitin-Protein Ligases (metabolism), Xenograft Model Antitumor Assays.
• MESH :
  • chemical , analogs & derivatives : Phosphorylcholine.
  • chemical , metabolism : Cell Cycle Proteins, F-Box Proteins, Glycogen Synthase Kinase 3, Oncogene Protein v-akt, Protein Kinases, Ubiquitin-Protein Ligases.
  • drug effects : Autophagy, Phosphorylation, Signal Transduction.
  • drug therapy : Lung Neoplasms.
  • metabolism : Lung Neoplasms.
  • pathology : Lung Neoplasms.
  • chemical , pharmacology : Chloroquine, Phosphorylcholine.
  • Animals, Cell Line, Tumor, F-Box-WD Repeat-Containing Protein 7, Female, HCT116 Cells, Humans, Mice, Mice, Nude, TOR Serine-Threonine Kinases, Xenograft Model Antitumor Assays.

Abstract

Affiliations:

• États-Unis

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